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Differin is used for treating severe acne.

Over the counter substitute for adapalene (2.5 mg). Both were given with a glass of water, to which the patients were advised not to add hot beverages or any other is adapalene generic source of heat. Patients reported to hospital on the night of study commenced in June 1992. There were no withdrawals or adverse reactions before after starting the medication. Patients The study sample consisted of 16 subjects with drugstore rx scar gel acne. Seventeen were female and one was male. Both sexes were of similar age, had a mean (±SD) age of 17.7 ± 1.6 at arrival, had generic adapalene price a lower mean (±SD) body mass index of 14.8 ± 0.5 kg/m2 (14.0–17.3 in female), and had low (±SD) self-reported educational level and ethnic origin. No patient had received acne therapy in the previous 3 months, and no treatment with topical retinoids, antibiotics, or antiandrogens had been prescribed previously. The majority of patients (60%) presented severe, recalcitrant acne [ ]. Subjects were not excluded from the study if they had acne of less severe severity on the initial evaluation and were otherwise unaffected. None of the subjects had a diagnosis of acne-associated alopecia. Most (85%) had been treated clinically with antibiotics or topical retinoids, including erythromycin in 17 (18%) and plus topical retinoids in 16 (19%). One patient treated with erythromycin alone developed mild perianal acne and was excluded from the study. Other antiandrogens were also used in 20 (21%), including spironolactone 10 mg twice daily for 6 days in 16 (20%), clindamycin 5–10 mg twice daily in 14 (18%), and clindamycin plus spironolactone in 12 (14%). All subjects were receiving acne therapy, with erythromycin or clindamycin at least once daily for 3 months or more. Patients treated with topical retinoids were receiving either 1% tretinoin gel (Nemotran ®; S.D. Wyeth/Gilead, Dublin, Ireland) or 1% hydrocortisone gel (Actonel ®; E.I. du Pont de Nemours-Siemens, Rixensart, France). The patient's parents were informed of the purpose and procedures before study entry. They were reimbursed for the visit or consultations. study was approved by the Institutional Review Board of Columbia University Medical Center (University Place, New York, NY, USA). Study design Patients treated with adapalene or clindamycin were enrolled from the acne clinic at Columbia University Medical Center during the study period of June 1992 to spring 1993. The acne patients were re